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Publication : The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression.

First Author  Sundaresan V Year  1998
Journal  Mol Cell Neurosci Volume  11
Issue  1-2 Pages  29-35
PubMed ID  9608531 Mgi Jnum  J:47685
Mgi Id  MGI:1203925 Doi  10.1006/mcne.1998.0672
Citation  Sundaresan V, et al. (1998) The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci 11(1-2):29-35
abstractText  A new member of the NCAM family mapping to 3p12 has been isolated and predicted to be arranged in five immunoglobulin-like domains and three fibronectin-like domains which are particularly homologous to L1. There is a transmembrane domain and a long cytoplasmic region with no detectable homology to other sequences. Although less closely related to DCC, another family member, both share a loop of positively charged amino acids within the first immunoglobulin domain, unique to these two members of this very large gene family. Preliminary studies of expression in mouse embryos support an inferred role in neural development, but the observation of widespread gene expression in adult human tissues indicates that this protein has additional functions to those performed in neural cells.
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