| First Author | Williams AS | Year | 2022 |
| Journal | iScience | Volume | 25 |
| Issue | 1 | Pages | 103635 |
| PubMed ID | 35028529 | Mgi Jnum | J:322280 |
| Mgi Id | MGI:6854207 | Doi | 10.1016/j.isci.2021.103635 |
| Citation | Williams AS, et al. (2022) Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome. iScience 25(1):103635 |
| abstractText | Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, mitochondrial function, and/or the activities of NAD-dependent sirtuin deacetylase enzymes. This investigation examined the impact of NRS on whole body energy homeostasis, skeletal muscle mitochondrial function, and corresponding shifts in the acetyl-lysine proteome, in the context of diet-induced obesity using C57BL/6NJ mice. The study also included a genetically modified mouse model that imposes greater demand on sirtuin flux and associated NAD(+) consumption, specifically within muscle tissues. In general, whole body glucose control was marginally improved by NRS when administered at the midpoint of a chronic high-fat diet, but not when given as a preventative therapy upon initiation of the diet. Contrary to anticipated outcomes, the study produced little evidence that NRS increases tissue NAD(+) levels, augments mitochondrial function, and/or mitigates diet-induced hyperacetylation of the skeletal muscle proteome. |
