| First Author | Pokhrel RH | Year | 2022 |
| Journal | Int J Mol Sci | Volume | 23 |
| Issue | 20 | PubMed ID | 36293240 |
| Mgi Jnum | J:333897 | Mgi Id | MGI:7379411 |
| Doi | 10.3390/ijms232012384 | Citation | Pokhrel RH, et al. (2022) AMPK Amplifies IL2-STAT5 Signaling to Maintain Stability of Regulatory T Cells in Aged Mice. Int J Mol Sci 23(20) |
| abstractText | AMP-activated protein kinase (AMPK), an important regulator of the aging process, is expressed in various immune cells. However, its role in regulatory T cell (Treg) stability during aging is poorly understood. Here, we addressed the role of AMPK in Treg function and stability during aging by generating Treg-specific AMPKalpha1 knockout mice. In this study, we found that AMPKalpha1-deficient Tregs failed to control inflammation as effectively as normal Tregs did during aging. AMPK knockout from Tregs reduces STAT5 phosphorylation in response to interleukin (IL)-2 stimulation, thereby destabilizing Tregs by decreasing CD25 expression. Thus, our study addressed the role of AMPK in Tregs in sensing IL-2 signaling to amplify STAT5 phosphorylation, which, in turn, supports Treg stability by maintaining CD25 expression and controlling inflamm-aging. |
