| First Author | Lesage F | Year | 1997 |
| Journal | FEBS Lett | Volume | 402 |
| Issue | 1 | Pages | 28-32 |
| PubMed ID | 9013852 | Mgi Jnum | J:38116 |
| Mgi Id | MGI:85503 | Doi | 10.1016/s0014-5793(96)01491-3 |
| Citation | Lesage F, et al. (1997) The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett 402(1):28-32 |
| abstractText | The two P domain K+ channel mTWIK-1 has been cloned from mouse brain. In Xenopus oocytes, mTWIK-1 currents are K+-selective, instantaneous, and weakly inward rectifying. These currents are blocked by Ba2+ and quinine, decreased by protein kinase C and increased by internal acidification. The apparent molecular weight of mTWIK-1 in brain is 81 kDa. A 40 kDa form is revealed after treatment with a reducing agent, strongly suggesting that native mTWIK-1 subunits dimerize via a disulfide bridge. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney, and skeletal muscle. In situ hybridization shows that mTWIK-1 expression is restricted to a few brain regions, with the highest levels in cerebellar granule cells, brainstem, hippocampus and cerebral cortex. |
