First Author | Karakozova M | Year | 2006 |
Journal | Science | Volume | 313 |
Issue | 5784 | Pages | 192-6 |
PubMed ID | 16794040 | Mgi Jnum | J:110637 |
Mgi Id | MGI:3640753 | Doi | 10.1126/science.1129344 |
Citation | Karakozova M, et al. (2006) Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science 313(5784):192-6 |
abstractText | Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells. Arginylation of beta-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis. |