| Primary Identifier | MGI:1921585 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 74335 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to act upstream of or within DNA damage response and DNA recombination. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Is expressed in several structures, including adipose tissue; adrenal gland; brain; gonad; and submandibular gland. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). PHENOTYPE: Mice homozygous for a null allele exhibit growth arrest at the 6-8 somite stage prior to axial rotation and embryonic lethality during organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
