| First Author | Christenson Wick Z | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31609204 | Mgi Jnum | J:284537 |
| Mgi Id | MGI:6382223 | Doi | 10.7554/eLife.46816 |
| Citation | Christenson Wick Z, et al. (2019) Novel long-range inhibitory nNOS-expressing hippocampal cells. Elife 8:e46816 |
| abstractText | The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal neurons which we refer to as LINCs, as they are long-range inhibitory neuronal nitric oxide synthase (nNOS)-expressing cells. LINCs project to several extrahippocampal regions including the tenia tecta, diagonal band, and retromammillary nucleus, but also broadly target local CA1 cells. LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregional coherence. The identification and characterization of these novel cells advances our basic understanding of both hippocampal circuitry and neuronal diversity. |
