| Primary Identifier | MGI:1202386 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 104346 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables microtubule binding activity and small GTPase binding activity. Involved in flagellated sperm motility; positive regulation of protein localization to cilium; and positive regulation of smoothened signaling pathway. Acts upstream of or within several processes, including axoneme assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Located in Golgi apparatus; ciliary basal body; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). PHENOTYPE: Mice homozygous for a gene trap allele exhibit postnatal lethality, severe hydrocephaly, situs inversus with levocardia and abnormal cilia morphology and function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
