| Primary Identifier | MGI:1857799 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Zeb1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A lacZ-neo cassette including termination signals replaced exon 1. The targeted allele encodes a fusion protein that lacks the DNA-binding and homeodomains functionally essential to the endogenous protein. Northern blot analysis showed an absence of normal transcript in homozygous mutant embryos. The expression pattern of beta-galactosidase largely resembled that of the endogenous gene, with the noted exception of expression in the notochord. |
