| First Author | Murata T | Year | 2014 |
| Journal | Sci Rep | Volume | 4 |
| Pages | 6959 | PubMed ID | 25376241 |
| Mgi Jnum | J:250490 | Mgi Id | MGI:6101833 |
| Doi | 10.1038/srep06959 | Citation | Murata T, et al. (2014) beta-CateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia. Sci Rep 4:6959 |
| abstractText | Wnt/beta-catenin signalling regulates numerous developmental and homeostatic processes. Ctnnb1 (also known as beta-catenin) is the only protein that transmits signals from various Wnt ligands to downstream genes. In this study, we report that our newly established mouse strain, which harbours a Cys429 to Ser missense mutation in the beta-catenin gene, exhibited specific organ defects in contrast to mice with broadly functioning Wnt/beta-catenin signalling. Both homozygous mutant males and females produced normal gametes but were infertile because of abnormal seminal vesicle and vaginal morphogenesis. An ins-TOPGAL transgenic reporter spatiotemporally sustained Wnt/beta-catenin signalling during the corresponding organogenesis. Therefore, beta-catenin(C429S) should provide new insights into beta-catenin as a universal component of Wnt/beta-catenin signal transduction. |
