| First Author | Lezama-Dávila CM | Year | 1995 |
| Journal | Mem Inst Oswaldo Cruz | Volume | 90 |
| Issue | 1 | Pages | 51-8 |
| PubMed ID | 8524085 | Mgi Jnum | J:40670 |
| Mgi Id | MGI:708031 | Doi | 10.1590/s0074-02761995000100012 |
| Citation | Lezama-Davila CM, et al. (1995) CD4+, CD8+ and CD4- CD8- T cell-subsets can confer protection against Leishmania m. mexicana infection. Mem Inst Oswaldo Cruz 90(1):51-8 |
| abstractText | We studied the role of CD4+, CD8+, CD4- CD8- T cells and IgG anti-Leishmania after infection or vaccination in the CBA/ca mouse. Mice were either infected with L. m. mexicana promastigotes or vaccinated with parasite-membrane antigens incorporated into liposomes. Successfully vaccinated mice were used as cell-donors in adoptive transfer experiments. Naive, syngeneic recipients received highly-enriched CD4+, CD8+ or CD4- CD8- T cells from those two set of donors and challenged with live parasites. Our results showed that, both CD4+ and CD8+ T cells from infected or vaccinated donors conferred significant disease-resistance to naive recipients. In addition, adoptive transfer of CD4- CD8- T cells from vaccinated donors significantly delayed lesion growth in recipient mice. We concluded that vaccination of CBA mice correlates with the induction of protective CD4+, CD8+ and CD4- CD8- T cells and the synthesis of IgG anti-Leishmania. |
