| First Author | Stumm RK | Year | 2003 |
| Journal | J Neurosci | Volume | 23 |
| Issue | 12 | Pages | 5123-30 |
| PubMed ID | 12832536 | Mgi Jnum | J:84362 |
| Mgi Id | MGI:2667490 | Doi | 10.1523/JNEUROSCI.23-12-05123.2003 |
| Citation | Stumm RK, et al. (2003) CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci 23(12):5123-30 |
| abstractText | The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated striatal precursors. In addition, we show that CXCR4 is present in early generated Cajal-Retzius cells of the cortical marginal zone. In mice with a null mutation in CXCR4 or SDF-1, interneurons were severely underrepresented in the superficial layers and ectopically placed in the deep layers of the neocortex. In contrast, the submeningeal positioning of Cajal-Retzius cells was unaffected. Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development. |
