| First Author | Baruzzi A | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 1 | Pages | 15-21 |
| PubMed ID | 19903482 | Mgi Jnum | J:155307 |
| Mgi Id | MGI:4413490 | Doi | 10.1016/j.febslet.2009.11.009 |
| Citation | Baruzzi A, et al. (2010) c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett 584(1):15-21 |
| abstractText | Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration. |
