| First Author | Quintero GC | Year | 2008 |
| Journal | Neurosci Lett | Volume | 437 |
| Issue | 1 | Pages | 55-8 |
| PubMed ID | 18423864 | Mgi Jnum | J:136801 |
| Mgi Id | MGI:3797147 | Doi | 10.1016/j.neulet.2008.03.077 |
| Citation | Quintero GC, et al. (2008) Evaluation of morphine analgesia and motor coordination in mice following cortex-specific knockout of the N-methyl-d-aspartate NR1-subunit. Neurosci Lett 437(1):55-8 |
| abstractText | Studies have shown that N-methyl-d-aspartate (NMDA) receptors play a critical role in morphine analgesia and motoric processes at different levels of the central nervous system. In this study, we used cortex-specific NR1 knockout (KO) mice (C57BL/6 strain) to elucidate the role of cortical NMDA receptors in morphine analgesia and motor coordination. On post-natal day 20, mice (CTL and KO) received vehicle (saline) or morphine (10mg/kg) and paw withdrawal latency (PWL) to a noxious thermal stimulus was measured. On post-natal day 21, motor coordination was measured using the rotating pole test. No differences in KO mice were found with respect to PWL following administration of saline or morphine (p>0.05). However, sex-dependent differences were found in motor coordination, with male KO mice showing a greater motor impairment in the rotating pole test than female KO mice (p<0.05). The present results demonstrate that NMDA receptors are involved in both the analgesic effects of morphine and motor coordination, with the existence of sex-related differences in motor coordination. |
