| First Author | Freigang S | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 10 | Pages | 1045-53 |
| PubMed ID | 23995233 | Mgi Jnum | J:208219 |
| Mgi Id | MGI:5562495 | Doi | 10.1038/ni.2704 |
| Citation | Freigang S, et al. (2013) Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53 |
| abstractText | Chronic inflammation is a fundamental aspect of metabolic disorders such as obesity, diabetes and cardiovascular disease. Cholesterol crystals are metabolic signals that trigger sterile inflammation in atherosclerosis, presumably by activating inflammasomes for IL-1beta production. We found here that atherogenesis was mediated by IL-1alpha and we identified fatty acids as potent inducers of IL-1alpha-driven vascular inflammation. Fatty acids selectively stimulated the release of IL-1alpha but not of IL-1beta by uncoupling mitochondrial respiration. Fatty acid-induced mitochondrial uncoupling abrogated IL-1beta secretion, which deviated the cholesterol crystal-elicited response toward selective production of IL-1alpha. Our findings delineate a previously unknown pathway for vascular immunopathology that links the cellular response to metabolic stress with innate inflammation, and suggest that IL-1alpha, not IL-1beta, should be targeted in patients with cardiovascular disease. |
