| First Author | Kovacic B | Year | 2006 |
| Journal | Cancer Cell | Volume | 10 |
| Issue | 1 | Pages | 77-87 |
| PubMed ID | 16843267 | Mgi Jnum | J:110949 |
| Mgi Id | MGI:3652442 | Doi | 10.1016/j.ccr.2006.05.025 |
| Citation | Kovacic B, et al. (2006) STAT1 acts as a tumor promoter for leukemia development. Cancer Cell 10(1):77-87 |
| abstractText | The tumor suppressor STAT1 is considered a key regulator of the surveillance of developing tumors. Here, we describe an unexpected tumor-promoting role for STAT1 in leukemia. STAT1(-/-) mice are partially protected from leukemia development, and STAT1(-/-) tumor cells induce leukemia in RAG2(-/-) and immunocompetent mice with increased latency. The low MHC class I protein levels of STAT1(-/-) tumor cells enable efficient NK cell lysis and account for the enhanced tumor clearance. Strikingly, STAT1(-/-) tumor cells acquire increased MHC class I expression upon leukemia progression. These findings define STAT1 as a tumor promoter in leukemia development. Furthermore, we describe the upregulation of MHC class I expression as a general mechanism that allows for the escape of hematopoietic malignancies from immune surveillance. |
