| First Author | Flies DB | Year | 2015 |
| Journal | J Immunol | Volume | 194 |
| Issue | 11 | Pages | 5294-304 |
| PubMed ID | 25917101 | Mgi Jnum | J:244952 |
| Mgi Id | MGI:5913731 | Doi | 10.4049/jimmunol.1402648 |
| Citation | Flies DB, et al. (2015) Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. J Immunol 194(11):5294-304 |
| abstractText | PD-1H is a recently identified cell surface coinhibitory molecule of the B7/CD28 immune modulatory gene family. We showed previously that single injection of a PD-1H agonistic mAb protected mice from graft-versus-host disease (GVHD). In this study, we report two distinct mechanisms operate in PD-1H-induced T cell tolerance. First, signaling via PD-1H coinhibitory receptor potently arrests alloreactive donor T cells from activation and expansion in the initiation phase. Second, donor regulatory T cells are subsequently expanded to maintain long-term tolerance and GVHD suppression. Our study reveals the crucial function of PD-1H as a coinhibitory receptor on alloreactive T cells and its function in the regulation of T cell tolerance. Therefore, PD-1H may be a target for the modulation of alloreactive T cells in GVHD and transplantation. |
