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Protein Coding Gene : Fgf22 fibroblast growth factor 22

Primary Identifier  MGI:1914362 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  67112
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in regulation of synapse maturation and trans-synaptic signaling. Located in Golgi apparatus; cell surface; and nucleolus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Is extrinsic component of postsynaptic density membrane. Is expressed in brain; early conceptus; gonad; spinal cord; and tongue. Orthologous to human FGF22 (fibroblast growth factor 22).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired vesicle clustering in glutamatergic synapses, decreased miniature excitatory postsynaptic currents, enhanced paired-pulse facilitation, increased synaptic depression, and decreased susceptibility topentylenetetrazol-induced seizures. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2210414E06 gene,
  • fibroblast growth factor 22,
  • Fgf22,
  • 2210414E06Rik

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Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

36 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For