| First Author | Kelley KA | Year | 1983 |
| Journal | Gene | Volume | 26 |
| Issue | 2-3 | Pages | 181-8 |
| PubMed ID | 6689487 | Mgi Jnum | J:7380 |
| Mgi Id | MGI:55851 | Doi | 10.1016/0378-1119(83)90188-9 |
| Citation | Kelley KA, et al. (1983) Mapping of murine interferon-alpha genes to chromosome 4. Gene 26(2-3):181-8 |
| abstractText | A cDNA library was constructed from polysomal poly(A)+RNA from Newcastle disease virus (NDV)-induced mouse C243 cells, and screened with a human interferon-alpha (HuIFN-alpha) cDNA probe. A cDNA clone for one of the murine interferon-alpha (MuIFN-alpha) genes was isolated, and sequencing analysis revealed that it was a partial copy which is almost identical to the published sequence for the MuIFN-alpha 2 gene. This partial cDNA clone represents a virus-induced message as seen by Northern blot analysis of RNA from NDV-induced C243 cells, and Southern blot analysis of DNA from BALB/c mouse revealed the presence of a multiple IFN-alpha gene family. The MuIFN-alpha genes were mapped to chromosome 4 by Southern blot analysis of hamster/mouse somatic cell hybrid DNAs. |
