| First Author | Hsiang YH | Year | 1995 |
| Journal | J Immunol | Volume | 154 |
| Issue | 10 | Pages | 5195-204 |
| PubMed ID | 7730626 | Mgi Jnum | J:25046 |
| Mgi Id | MGI:72760 | Doi | 10.4049/jimmunol.154.10.5195 |
| Citation | Hsiang YH, et al. (1995) The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. J Immunol 154(10):5195-204 |
| abstractText | An enhancer has been localized 3 kb downstream of the C gamma 1 gene segment of the murine TCR-gamma locus. One element, the gamma 3 site, has been shown to be critical for its functional activity. Here we have determined that Myb-related transcription factors bind to the gamma 3 site and appear to be critical for the full activity of the TCR-gamma enhancer. c-myb products can transactivate the gamma 3 site in cell lines that do not ordinarily support enhancer activity of the gamma 3 site. Mutations in the myb site or an adjacent site for core-binding factor(s) prevent transactivation. c-myb expression in various cell lines is consistent with their capacity to activate the gamma 3 enhancer element using transient transfection assays. Therefore, c-Myb or a related factor appears to play an important role in regulating the murine TCR-gamma enhancer. |
