Primary Identifier | MGI:4830150 | Allele Type | Targeted |
Gene | Ace | Transmission | Germline |
Strain of Origin | 129 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 20 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of lysines for histidines at positions 993 and 997 (H993K and H997K). A floxed neo cassette was inserted upstream of the modified exon. The absence of protein expression was confirmed by western blot analysis. |