| Primary Identifier | IPR009001 | Type | Homologous_superfamily |
| Short Name | Transl_elong_EF1A/Init_IF2_C |
| description | A beta barrel of circularly permuted topology is found in the C terminus of many translation elongation and initiation factors. This domain is found in the elongation factors EF1A (or EF-Tu) of both eukaryotes and prokaryotes, which functions to recognise and transport aminoacyl-tRNA to the acceptor (A) site of the ribosome during the elongation process [, ]. This domain is also found in the initiation factor IF2 gamma subunit of eukaryotes [], which functions to transport the initiator methionyl-tRNA to the ribosome. The C-terminal extension of mitochondrial EF1A (or EF-Tu) has structural similarities with DNA recognising zinc fingers, suggesting that the extension may be involved in recognition of RNA. |
