| First Author | Tu H | Year | 2003 |
| Journal | J Neuroimmunol | Volume | 139 |
| Issue | 1-2 | Pages | 145-9 |
| PubMed ID | 12799032 | Mgi Jnum | J:119039 |
| Mgi Id | MGI:3701040 | Doi | 10.1016/s0165-5728(03)00126-7 |
| Citation | Tu H, et al. (2003) Evidence for endogenous interleukin-10 during nociception. J Neuroimmunol 139(1-2):145-9 |
| abstractText | Cytokines such as IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) have been shown to contribute directly to central and peripheral neuropathic pain. Recently, exogenous interleukin-10 (IL-10) was shown to impede development of dynorphin-induced allodynia presumably by inhibiting IL-1beta. We therefore wanted to determine whether endogenous IL-10 had a role in pain perception. By measuring the latency of the paw licking response, we show in IL-10 knockout mice and in normal mice treated with anti-IL-10 that latency times are increased, suggesting that endogenous IL-10 increases nociception. This does not appear to be directly correlated with IL-10's regulation of DREAM, a transcriptional regulator of prodynorphin synthesis. |
