| First Author | Haberzettl R | Year | 2013 |
| Journal | Behav Brain Res | Volume | 256 |
| Pages | 328-45 | PubMed ID | 24004848 |
| Mgi Jnum | J:206849 | Mgi Id | MGI:5553041 |
| Doi | 10.1016/j.bbr.2013.08.045 | Citation | Haberzettl R, et al. (2013) Animal models of the serotonin syndrome: a systematic review. Behav Brain Res 256:328-45 |
| abstractText | The serotonin syndrome (SS) is a potentially life-threatening disorder in humans which is induced by ingestion of an overdose or by combination of two or more serotonin (5-HT)-enhancing drugs. In animals, acute administration of direct and indirect 5-HT agonists also leads to a set of behavioral and autonomic responses. In the current review, we provide an overview of the existing versions of the animal model of the SS. With a focus on studies in rats and mice, we analyze the frequency of behavioral and autonomic responses following administration of 5-HT-enhancing drugs and direct 5-HT agonists administered alone or in combination, and we briefly discuss the receptor mediation of these responses. Considering species differences, we identify a distinct set of behavioral and autonomic responses that are consistently observed following administration of direct and indirect 5-HT agonists. Finally, we discuss the importance of a standardized assessment of SS responses in rodents and the utility of animal models of the SS in translational studies, and provide suggestions for future research. |
