| Primary Identifier | IPR031295 | Type | Family |
| Short Name | Anoctamin-6 |
| description | The anoctamin/TMEM16 family members include Ano1-10 (TMEM16A-J). They are membrane proteins involved in a variety of physiological functions, such as ion transport and ion channel regulation. TMEM16A and 16B are Ca(2+)-dependent Cl(-) channels; TMEM16C, 16D, 16F, 16G, and 16J have been classified as Ca(2+)-dependent lipid scramblases []. The anoctamin/TMEM16 family might have diverged in two or three different subclasses, channels, scramblases and dual-function channel/scramblases [].Anoctamin-6 (Ano6, TMEM16F) has calcium-dependent phospholipid scramblase activity []. Ano6 is a Ca(2+)-activated Cl(-) required for lipid scrambling in platelets during blood coagulation []and has an important role in chemokine-induced dendritic cell migration []. It is an essential component of the immune defense by macrophages []. Ano6 is a component of the outwardly rectifying chloride channel (ORCC) in airway epithelial cells and Jurkat T lymphocytes []. The Na(+)/Ca(2+) exchanger NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix []. |
