| Primary Identifier | MGI:2386030 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 242425 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable G protein-coupled GABA receptor activity and protein heterodimerization activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm and neuron projection. Is expressed in brain; eye; and liver. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). PHENOTYPE: Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
