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Protein Coding Gene : Csk c-src tyrosine kinase

Primary Identifier  MGI:88537 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  12988
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable several functions, including enzyme binding activity; non-membrane spanning protein tyrosine kinase activity; and proline-rich region binding activity. Acts upstream of or within negative regulation of cell population proliferation. Located in cell-cell junction. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and liver and biliary system. Orthologous to human CSK (C-terminal Src kinase).
PHENOTYPE: Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten. [provided by MGI curators]
  • synonyms:
  • MGI:2143301,
  • c-src tyrosine kinase,
  • Csk,
  • AW212630,
  • MGD-MRK-2195,
  • expressed sequence AW212630

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

25 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For