| First Author | Zuercher G | Year | 2000 |
| Journal | Mech Dev | Volume | 93 |
| Issue | 1-2 | Pages | 175-7 |
| PubMed ID | 10781952 | Mgi Jnum | J:62058 |
| Mgi Id | MGI:1858285 | Doi | 10.1016/s0925-4773(00)00255-0 |
| Citation | Zuercher G, et al. (2000) A novel member of the testis specific serine kinase family, tssk-3, expressed in the leydig cells of sexually mature mice. Mech Dev 93(1-2):175-7 |
| abstractText | We have recently characterized two members of a novel family of murine testis specific serine kinases, tssk-1 and tssk-2, expressed exclusively in spermatids undergoing spermiogenesis. Using a differential screening approach we have isolated a third family member, tssk-3. The open reading frame of tssk-3 encodes a protein of 275 amino acids, consisting essentially of a serine/threonine protein kinase domain only. In contrast, tssk-1 and -2 have distinct, approximately 100 amino acid domains located C-terminally to the kinase domain. Immunoprecipitation experiments revealed that while tssk-1 and tssk-2 form detergent resistant complexes, tssk-3 is not associated with either protein. Expression of tssk-3 was induced at puberty, persisted during adulthood and was restricted to the interstitial Leydig cells of post-pubertal males. |
