| Primary Identifier | MGI:7571457 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Drd2 |
| Strain of Origin | C57BL/6NJ | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Guide RNA [GACCCGCUUCCGACGCUUG] is used to insert an isoleucine to phenylalanine substitution at position 212 (c.634 A to T) in exon 5. Drd2 transcript Drd2-201 (ENSMUST00000075764.8) was utilized as reference for the exon number and guide sequences. In humans, the I212F mutation is associated with progressive chorea and cervical dystonia. |
