| First Author | Chiba S | Year | 2014 |
| Journal | Elife | Volume | 3 |
| Pages | e04177 | PubMed ID | 25149452 |
| Mgi Jnum | J:291649 | Mgi Id | MGI:6207349 |
| Doi | 10.7554/eLife.04177 | Citation | Chiba S, et al. (2014) Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife 3:e04177 |
| abstractText | The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications. |
