| First Author | Do JS | Year | 2011 |
| Journal | J Immunol | Volume | 186 |
| Issue | 8 | Pages | 4546-50 |
| PubMed ID | 21402889 | Mgi Jnum | J:172525 |
| Mgi Id | MGI:5008214 | Doi | 10.4049/jimmunol.1004021 |
| Citation | Do JS, et al. (2011) Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ gammadelta T cells. J Immunol 186(8):4546-50 |
| abstractText | Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study, we report that a subset of IL-17(+) gammadelta T cells plays a crucial role in enhancing in vivo Th17 differentiation and T cell-mediated colitis. TCRbeta(-/-) mice were highly susceptible to T cell-mediated colitis, whereas TCRbetadelta(-/-) mice were resistant to the disease. Importantly, cotransfer of IL-17(+) but not of IL-17(-) gammadelta T cells with CD4 T cells was sufficient to enhance Th17 differentiation and induce full-blown colitis in TCRbetadelta(-/-) recipients. Collectively, our results provide a novel function of IL-17(+) gammadelta T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation. |
