| First Author | Wang X | Year | 1992 |
| Journal | J Biol Chem | Volume | 267 |
| Issue | 13 | Pages | 9176-84 |
| PubMed ID | 1374386 | Mgi Jnum | J:823 |
| Mgi Id | MGI:49357 | Doi | 10.1016/s0021-9258(19)50405-7 |
| Citation | Wang X, et al. (1992) Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. J Biol Chem 267(13):9176-84 |
| abstractText | We previously reported the structure of the placentally derived human cysteine-rich (h crp) cDNA and demonstrated that it encodes a highly conserved and widely distributed zinc finger-like protein. We now report that the expression of both the mouse and human crp genes is induced as a primary response to serum in quiescent Balb/c 3T3 cells and in human fibroblasts. The profile of this primary response is remarkably parallel to that of c-myc in the Balb/c 3T3 cell line. The structure of the 23.2-kilobase h crp gene demonstrates that it is a member of a gene superfamily encoding proteins sharing a highly characteristic 52-amino acid LIM/double-finger motif. The evolutionarily conserved structure of cysteine-rich protein, its structural similarity to a number of developmentally critical proteins, its distinctive tissue distribution, and its primary response to early events in the cell cycle suggest that crp plays an important role in cell function. |
