| First Author | Akerblom M | Year | 2014 |
| Journal | Development | Volume | 141 |
| Issue | 7 | Pages | 1580-8 |
| PubMed ID | 24598163 | Mgi Jnum | J:208649 |
| Mgi Id | MGI:5563876 | Doi | 10.1242/dev.101659 |
| Citation | Akerblom M, et al. (2014) microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons. Development 141(7):1580-8 |
| abstractText | New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification. |
