| First Author | Nakamizo S | Year | 2015 |
| Journal | J Invest Dermatol | Volume | 135 |
| Issue | 4 | Pages | 1007-1015 |
| PubMed ID | 25493651 | Mgi Jnum | J:220037 |
| Mgi Id | MGI:5632056 | Doi | 10.1038/jid.2014.516 |
| Citation | Nakamizo S, et al. (2015) Dermal Vgamma4(+) gammadelta T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8(+) T-Cell Activity through TNF-alpha Production. J Invest Dermatol 135(4):1007-15 |
| abstractText | A large number of gamma delta T cells (gammadelta T cells) are located within epithelial tissues including the skin. In mice, epidermal and dermal gammadelta T cells consist of distinct subsets and have specific roles in cutaneous immune responses. A recent study demonstrated that gammadelta T cells and cutaneous dendritic cells migrate from the skin to the draining lymph nodes (LNs). However, it remains unclear whether they regulate the antigen-specific immune response within the LNs. Herein, we investigated their properties and role in the LNs using the Mycobacterium bovis bacille Calmette-Guerin (BCG) infection model. In vivo cell labeling analysis revealed that most of the migratory subset comprised dermal Vgamma4(+) cells. This population transmigrated from the skin to the LNs in a Gi-coupled chemokine receptor-independent manner. By depleting Vgamma4(+) cells, the intranodal expansion of CD8(+) T cell against BCG was significantly attenuated. In addition, in vitro analysis revealed that Vgamma4(+) cells produced TNF-alpha and enhanced IL-12 production by dendritic cells. Taken together, these findings suggest that dermal Vgamma4(+) cells are a unique subset that possesses a migratory potency to the skin-draining LNs and enhances the dendritic cell function therein. |
