| First Author | Sung TC | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 7 | Pages | e69286 |
| PubMed ID | 23935974 | Mgi Jnum | J:204945 |
| Mgi Id | MGI:5543757 | Doi | 10.1371/journal.pone.0069286 |
| Citation | Sung TC, et al. (2013) P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One 8(7):e69286 |
| abstractText | Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans. |
