| Primary Identifier | MGI:99655 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 12142 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables histone methyltransferase binding activity; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in gene expression and regulation of lymphocyte differentiation. Acts upstream of or within several processes, including circulatory system development; eye morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; retina; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1). PHENOTYPE: Homozygous null mice display embryonic lethality and impaired primordial germ cell development, while heterozygotes display a decreased numbers of primordial germ cells but normal migration. Conditional mutants display impaired plasma cell and pre-plasmamemory B cell development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
