| Primary Identifier | MGI:1343139 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 22781 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables bHLH transcription factor binding activity and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). PHENOTYPE: Homozygous knockout reduces proliferation rate of conventional T cells and causes increased susceptibility to experimental autoimmune encephalomyelitis. Conditional knockout in regulatory T cells (Tregs) results in enlarged spleen and lymph nodes and chronic inflammation of internal organs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
