| First Author | Leucht C | Year | 2004 |
| Journal | Transgenic Res | Volume | 13 |
| Issue | 1 | Pages | 81-5 |
| PubMed ID | 15070079 | Mgi Jnum | J:89013 |
| Mgi Id | MGI:3037607 | Doi | 10.1023/b:trag.0000017177.35197.89 |
| Citation | Leucht C, et al. (2004) Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA. Transgenic Res 13(1):81-5 |
| abstractText | The 37-kDa/67-kDa laminin receptor (LRP/LR) plays a major role in the propagation of PrPSc, the abnormal form of the prion protein. In order to ablate the expression of LRP/LR in mouse brain we generated transgenic mice ectopically expressing antisense LRP RNA in the brain under control of the neuron-specific enolase (NSE) promoter. Hemizygous transgenic mice TgN(NSEasLRP)2 showed a significant reduction of LRP/LR protein levels in hippocampal and cerebellar brain regions. These mice might act as powerful tools to investigate the role of the laminin receptor in scrapie pathogenesis. |
