Primary Identifier | MGI:1891445 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 93834 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein-macromolecule adaptor activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Located in cytosol and membrane. Is expressed in several structures, including neural tube; notochord; sensory organ; skeleton; and thymus. Orthologous to human PELI2 (pellino E3 ubiquitin protein ligase family member 2). PHENOTYPE: Homozygous knockout reduces the immune response to gram-negative bacteria. [provided by MGI curators] |