| First Author | Gu X | Year | 2001 |
| Journal | J Biol Chem | Volume | 276 |
| Issue | 12 | Pages | 9421-36 |
| PubMed ID | 11108721 | Mgi Jnum | J:68188 |
| Mgi Id | MGI:1932235 | Doi | 10.1074/jbc.M010070200 |
| Citation | Gu X, et al. (2001) Tel-2 is a novel transcriptional repressor related to the ets factor tel/etv-6. J Biol Chem 276(12):9421-36 |
| abstractText | We report here the isolation of Tel-2, a novel member of the Ets transcription factor family, with high homology to Tel/ETV-6. Tel-2 is the second mammalian member of the Tel Ets family subclass whose prototype Tel is involved in various chromosomal translocations in human cancers. Six differentially expressed alternative splice products of Tel-2 were characterized encoding different Tel-2 isoforms which either contain or lack the amino-terminal Pointed domain and also vary at the carboxyl terminus. In contrast to Tel, which is highly expressed in several different cell types and tissues, Tel-2 is only weakly expressed in a variety of tissues and cell types, including placenta, prostate, spleen, liver, and lung. Tel-2 binds to functionally relevant Ets-binding sites of several genes and only the Tel-2 isoform containing the Pointed domain and the DNA-binding domain acts as a strong repressor of transcription. The retinoic acid receptor alpha and bone morphogenetic protein-6B (BMP-6) genes are specifically repressed by Tel-2 indicating a function for Tel-2 as an inhibitor of differentiation. Due to the important involvement of Tel in human cancer and the location of Tel-2 within the MHC cluster region, Tel-2 might be involved in chromosomal translocations in human cancer as well. |
