| Primary Identifier | MGI:1921325 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 74075 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in synaptonemal complex organization. Predicted to act upstream of or within synaptonemal complex assembly. Located in central element. Is expressed in gonad; metanephros; and submandibular gland. Used to study primary ovarian insufficiency 12. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 12 and spermatogenic failure 15. Orthologous to human SYCE1 (synaptonemal complex central element protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit small ovaries and small testes, severe defects in gametogenesis, and infertility in both sexes. Meiosis is arrested, homologous chromosomes fail to synapse, and meiotic double-strand breaks are formed but are not efficiently repaired. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
