| Primary Identifier | MGI:98923 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 22324 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables guanyl-nucleotide exchange factor activity and phosphorylation-dependent protein binding activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of natural killer cell mediated cytotoxicity. Located in cell-cell junction. Is expressed in several structures, including extraembryonic component; hemolymphoid system; liver; pancreas; and trunk mesenchyme. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). PHENOTYPE: Homozygous null mutants exhibit defective T cell maturation, interleukin-2 production, and cell cycle progression. Immunoglobulin class switching is also impaired and attributed to defective T cell help. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
