| First Author | Shimizu K | Year | 1999 |
| Journal | FEBS Lett | Volume | 456 |
| Issue | 2 | Pages | 295-300 |
| PubMed ID | 10456327 | Mgi Jnum | J:56927 |
| Mgi Id | MGI:1342905 | Doi | 10.1016/s0014-5793(99)00966-7 |
| Citation | Shimizu K, et al. (1999) The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett 456(2):295-300 |
| abstractText | Autocrine motility factor receptor (AMFR) is a cell surface glycoprotein of molecular weight 78,000 (gp78), mediating cell motility signaling in vitro and metastasis in vivo. Here, we cloned the full-length cDNAs for both human and mouse AMFR genes. Both genes encode a protein of 643 amino acids containing a seven transmembrane domain, a RING-H2 motif and a leucine zipper motif and showed a 94.7% amino acid sequence identity to each other. Analysis of the amino acid sequence of AMFR with protein databases revealed no significant homology with all known seven transmembrane proteins, but a significant structural similarity to a hypothetical protein of Caenorhabditis elegans, F26E4.11. Thus, AMFR is a highly conserved gene which encodes a novel type of seven transmembrane protein. |
