| Primary Identifier | MGI:1201686 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 13017 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including nuclear retinoic acid receptor binding activity; transcription coregulator activity; and transcription coregulator binding activity. A structural constituent of presynaptic active zone. Involved in negative regulation of DNA-templated transcription; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within cellular response to leukemia inhibitory factor; positive regulation of retinoic acid receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus and ribbon synapse. Part of transcription repressor complex. Is active in several cellular components, including photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Is expressed in several structures, including limb; lung; nervous system; sensory organ; and tooth. Orthologous to human CTBP2 (C-terminal binding protein 2). PHENOTYPE: Embryos homozygous for a gene-trapped allele die by E10 exhibiting a small size, axial truncations, a thin neural epithelium, a dilated pericardium, delayed fore- and midbrain development, and defects in heart morphogenesis, placental development and extraembryonic vascularization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
