| Primary Identifier | MGI:1917514 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 225467 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable heterocyclic compound binding activity and protein geranylgeranyltransferase activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell cycle; and positive regulation of cell population proliferation. Predicted to be part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). PHENOTYPE: Homozygous inactivation of this gene blocks proliferation of primary mouse fibroblasts, disrupts the actin cytoskeleton, and results in altered cell morphology and reduced cell migration in a standard wound healing assay. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
