| First Author | Janz R | Year | 1999 |
| Journal | Neuron | Volume | 24 |
| Issue | 3 | Pages | 687-700 |
| PubMed ID | 10595519 | Mgi Jnum | J:58559 |
| Mgi Id | MGI:1349221 | Doi | 10.1016/s0896-6273(00)81122-8 |
| Citation | Janz R, et al. (1999) Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24(3):687-700 |
| abstractText | We have generated mice lacking synaptogyrin I and synaptophysin I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles. Single and double knockout mice were alive and fertile without significant morphological or biochemical changes. Electrophysiological recordings in the hippocampal CA1 region revealed that short-term and long-term synaptic plasticity were severely reduced in the synaptophysin/synaptogyrin double knockout mice. LTP was decreased independent of the induction protocol, suggesting that the defect in LTP was not caused by insufficient induction. Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself. |
