| First Author | Fehling HJ | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5176 | Pages | 1234-7 |
| PubMed ID | 8066463 | Mgi Jnum | J:20012 |
| Mgi Id | MGI:68129 | Doi | 10.1126/science.8066463 |
| Citation | Fehling HJ, et al. (1994) MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265(5176):1234-7 |
| abstractText | Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery. |
