| First Author | Liu Y | Year | 2007 |
| Journal | Endocrinology | Volume | 148 |
| Issue | 2 | Pages | 683-92 |
| PubMed ID | 17068142 | Mgi Jnum | J:129554 |
| Mgi Id | MGI:3769645 | Doi | 10.1210/en.2006-0708 |
| Citation | Liu Y, et al. (2007) Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology 148(2):683-92 |
| abstractText | Adiponectin/adiponectin receptors (AdipoR) are involved in energy homeostasis and inflammatory pathways. To investigate the role of AdipoR2 in metabolic control, we studied the lipid and glucose metabolic phenotypes in AdipoR2-deficient mice. AdipoR2 deletion diminished high-fat diet-induced dyslipidemia and insulin resistance yet deteriorated glucose homeostasis as high-fat feeding continued, which resulted from the failure of pancreatic beta-cells to adequately compensate for the moderate insulin resistance. A defect in the AdipoR2 gene may represent a mechanism underlying the etiology of certain subgroups of type 2 diabetic patients who eventually develop overt diabetes, whereas other obese patients do not. |
