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Allele : Pfn3<em2Hsc> profilin 3; endonuclease-mediated mutation 2, Hubert Schorle

Primary Identifier  MGI:6384216 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Pfn3
Strain of Origin  (C57BL/6 x DBA)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 genome editing was used to delete 41 bp causing a frameshift in the reading frame that leads to a premature stop codon after amino acid 13. qRT-PCR, Western blotting, and immunohistochemistry confirmed the deletion in the testes of homozygous mutant mice.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Pfn3delta41,
  • Pfn3delta41
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele