| First Author | Sutton VR | Year | 1983 |
| Journal | J Immunol | Volume | 131 |
| Issue | 3 | Pages | 1363-7 |
| PubMed ID | 6193187 | Mgi Jnum | J:7173 |
| Mgi Id | MGI:55644 | Doi | 10.4049/jimmunol.131.3.1363 |
| Citation | Sutton VR, et al. (1983) Description of a new Qa antigenic specificity, Qa-m9, whose expression is under complex genetic control. J Immunol 131(3):1363-7 |
| abstractText | The Qa-m9 specificity has been defined by a monoclonal antibody, and evidence for three-gene control of its expression has been demonstrated. The Qa allocation was made on the basis of H-2 linkage (H-2 congenic strains, Rl lines), differential reaction with B6.K1 and B6.K2, and biochemical analysis (two chains: 39,000 Mr and 12,000 Mr). Qa-m9 is expressed on T and B cells in spleen and lymph node; it is present on a small population of bone marrow cells but is absent from thymocytes. The three genes involved in the expression of the antigen are: a) an H-2 linked Qa gene (possibly encoded by a gene different from Qa-2-6); b) an H-3 linked gene--probably beta 2m; and c) an H-2D linked gene that controls the amount of antigen present. It is likely that the determinant is of the combinatorial or conformational type, whereby the C57BL/6-type Qa heavy chain and the appropriate beta 2m light chain must both be in association. Thus, the study provides evidence for a multi-gene control of antigen expression and demonstrates the potential for generating new antigens with diversity at a post-translational level. |
